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Research Officer wanted immediately: APPLY HERE

Research Officer wanted immediately: APPLY HERE


(12 month contract)

Wellcome Centre for Infectious Diseases Research in Africa

Institute of Infectious Disease and Molecular Medicine

Faculty of Health Sciences
The AMBITION-cm trial is an open label phase III randomised controlled non-inferiority trial to compare single
dose L-AmB treatment to 7-day amphotericin B deoxycholate based treatment for HIV-associated cryptococcal
meningitis. The trial, funded by EDCTP and sponsored by the London School of Tropical Medicine and Hygiene, is
currently recruiting across 7 sites in Africa. The Cape Town site is based at UCT and is currently recruiting at
Mitchells Plain Hospital and will soon expand to Khayelitsha Hospital. The trial will recruit until mid 2020. The
national principal investigator is Professor Graeme Meintjes.
We are seeking a full time research medical officer to work across the two clinical sites in the Cape Town area. The
successful candidate will work closely with the current team, which includes a designated research nurse, study
coordinator, trial pharmacist, the site PI and sub-investigators. The primary responsibilities will be to recruit
patients to the study, assess and manage trial participants in both an inpatient and outpatient setting, perform
study procedures, collect clinical data, assist with data entry and management, safety reporting, and play a key
role in the administration and functioning of the clinical trial team.

The successful candidate will work within an established clinical trial team, and will have a large workload that
must be conducted according to the highest ethical standards with rigorous attention to data integrity and safety
considerations. The post will provide an excellent opportunity to learn about all aspects of clinical trial conduct as
well as becoming involved in the world renowned research conducted at the Institute of Infectious Disease and
Molecular Medicine (IDM).

This 12 months full-time contract post will be held at the Institute of Infectious Disease and Molecular Medicine
(IDM) within the Faculty of Health Sciences of the University of Cape Town (UCT). The
daily activities of this post will be 90% based at clinical research sites (the candidates will have to
travel between the two sites) and 10% at the IDM.

Effective start date: 1st July 2019 or as soon as possible


MBChB degree
Registration with the Health Professions Council of South Africa as Independent Medical Practitioner
Minimum of one year experience in management of HIV associated cryptococcal meningitis (it is
acceptable if these patients were managed under supervision as part of general medical rotation or
emergency room work)
Minimum of one year experience in management of HIV-infected patients hospitalized with opportunistic
infections (as above)
Minimum of 6 months experience in the conduct of clinical research
Experience in performance of lumbar punctures
Knowledge of Good Clinical Practice (GCP)
Computing skills appropriate for medical research
Fluency in written and spoken English
Excellent communication skills
Ability to work efficiently in a team
Valid work permit if not South African
Valid driver’s license


Postgraduate degree or diploma in clinical management of HIV infected patients
A high level of knowledge and experience in HIV management, so that the Medical Officer could assess
complex cases with HIV and cryptococcal meningitis co-infection independently and discuss management
problems with consultants as appropriate
Current accredited GCP certificate
Current accredited BLS/ACLS certificate
Ability to communicate in Afrikaans and/or isiXhosa
Track record of successfully working in a multidisciplinary clinical team

• Recruitment and follow-up of study participants, clinical assessment and management of participants

including practical study procedures such as lumbar puncture.
Oversight of the informed consent process.
Completion of all relevant study documentation according to study standard operating procedures and
Entry of study data onto electronic database.
Reporting of adverse events to sponsor, ethics committee and regulatory authorities with strict adherence
to guidelines.
Assist with study administration including writing of documents and communication, and development or
revision of study standard operating procedures (SOPs) as needed.

Liaison with data management team and maintenance of effective communication with the other study
staff and site staff members including principal investigator, lead investigator and study co-ordinator.
Effective communication with hospital staff regarding study participants.
Liaise closely and maintain effective communication with the study monitors and trial sponsors.
Management, supervision and teaching of clinical research staff as required by the project.
Transport of samples from clinical site to the laboratory if required
Attend study and academic meetings and training as required
Presentation of research findings at meetings at the clinical research sites and IDM.

Formal duties will not exceed 40 hours per week but flexible hours will be required with some work over

The annual cost of employment is R780 612, no benefits included.

Cover letter, and
Curriculum Vitae (CV)
Please ensure the title and reference number are indicated in the subject line.

An application which does not comply with the above requirements will be regarded as incomplete.
Only shortlisted candidates will be contacted and may be required to undergo an assessment.

Reference number: E90610 Closing date: 17 June 2019

The starting date is 01 July 2019

Apply Now

Source: Indeed